Prognosis and quality of life of survivors from ARDS
In a meta-analysis, an insertion/deletion (I/D) polymorphism
in the ACE gene was not associated with susceptibility
to ALI/ARDS for any genetic model. However, the ACE I/
D polymorphism was associated with an increased mortality
risk of ALI/ARDS in Asian subjects [49]. After correcting
for multiple comparisons, this finding remained
significant, and it was shown that the genotype of the I/D
polymorphism in ACE may be a predictor of ALI/ARDS
mortality in Asian populations [49].
Along with high mortality risks, survivors suffer significant
decrements in their quality of life [50]. In survivors
of acute lung injury, there was no difference in
physical function, survival, or multiple secondary outcomes
at 6 and 12 months follow-up after initial trophic
or full enteral feeding [51].