The availability of safe and effective coagulation factor replacement therapy for Hemophilia, von Willebrand's disease, and reversal of bleeding secondary to anticoagulants has narrowed the indications for plasma although inappropriate use still occurs [1]. Plasma is preferred in massive transfusion protocols (MTPs), resuscitation of patients with coagulopathy due to liver failure, and as replacement fluid in therapeutic plasma exchange for thrombotic thrombocytopenic purpura [2]. Although the indications for plasma have become very specific, there was a 27% increase in amount of AB plasma units distributed by 10 US blood centers in 2011 compared to 2006 [3]. This increased demand for AB plasma can be attributed to widespread adoption of MTPs [4] which depend initially on the universal AB plasma until the patient's blood type is identified, a greater number of hospitals maintaining a thawed plasma inventory [5], and the convenience of distributing universal AB plasma by cross-trained medical technologists staffing the blood bank.