Tissue engineering is an important approach inregenerative medicine for the development of artificialorgans for restoring, maintenance or improvement ofdamaged tissue functions. Three-dimensionalporous scaffolds are required to support the formationof new tissue, extra cellular matrix (ECM), cellularmigration, transport of nutrients and metabolic wastes. The scaffold should meet several requirementsdepending on the application.a controlled fabrication of 3Dbiodegradable scaffolds is a crucial step in the designof tissue engineering scaffolds. Structurally, micro,meso and macroscopic 3D shapes are generallydeveloped from natural and synthetic polymers by anumber of traditional methods such as particulateleaching , fiber-bonding, gas forming, freeze-dryingand