Pothos (Epipremnum aureum) is well-known as an easy, beginner’s houseplant. Although there is a best way to grow it, the plant tolerates a lot of abuse and continues to thrive. In nature, pothos is a climbing vine and this growth habit makes it an attractive feature in a hanging planter. Although the plant grows outdoors in the warmer regions within U.S. Department of Agriculture plant hardiness zones 10 and above, the best way to grow pothos is indoors, where you can control the environment.