Ghee (refined animal butterfat) has beneficial therapeutic
effects on healing process of the wound (Sharma, 1981). The most
important components of ghee are saturated fatty acid and polyunsaturated
fatty acid (PUFA) like linolenic acid (n-3), linoleic acid
(n-6) and oleic acid (n-9) (Bhavbhuti, 2006). PUFA in addition to
their structural role, can modulate cell–cell interaction and intracellular
signal transduction (Ruthig and Meckling-Gill, 1999). n-3
and n-6 PUFA are capable of stimulating epithelial cell proliferation
in vitro, a fundamental role during wound healing (Calder,
2001). PUFAs are also the primary precursors of many lipoic mediators
like arachidonic acid with crucial function in the inflammatory
process, like vascular contraction, chemotaxis, adhesion, transmigration
and cellular activation (Calder et al., 2002).