Barley (Hordeum vulgare L.) is a major food crop, and is used primarily as a cereal but also as an industrial commodity for the production of fermented commodities. β-glucans are the active component of barley (21) and exert beneficial effects on skin health, by decreasing hyaluronidase and collagenase expression. They also stimulate collagen protein expression, and reduce wrinkling both in vivo and in human subjects.(13) BS is itself a yeast fermentation product with enhanced daidzein, genistein, and β-glucan content.(14)