Authors' contributions
YS conceived the study, participated in its design, carried out most of the in vitro and in vivo studies, analyzed the data and participated in the preparation of the manuscript. LMR performed the western blots and part of the immunohistochemistry assays for in vivo studies. LH carried out the in vitro COX-2 expression experiments. GGM carried out the NF-κB electrophoretic mobility shift assays. KV synthesized batches of P-I. DK participated in study design and data analysis, provided P-I, and reviewed the manuscript. BR conceived the study, participated in its design, supervised the work, analyzed data and participated in writing the manuscript. All authors read and approved the final manuscript.