After successful fungal infection, 30 animals were divided randomly into 5 groups of 6 and treated with various drugs twice per day for 14 days. Three groups were treated with 20 l COS at concentrations of 0.1%, 1%, and 5%. The model control (MC) group was treated with 20 l distilled water. The FCZ group was treated with 20 l0.1% fluconazole.