Acute upper respiratory tract infections (URTIs), including the common cold and rhinosinusitis, are common afflictions that cause
discomfort and debilitation and contribute significantly to workplace absenteeism. Treatment is generally by antipyretic and decongestant
drugs and sometimes antibiotics, even though most infections are viral. Nasal irrigation with saline is often employed as an adjunct
treatment for URTI symptoms despite a relative lack of evidence for benefit in this clinical setting. This review is an update of the
Cochrane review by Kassel et al, which found that saline was probably effective in reducing the severity of some symptoms associated
with acute URTIs