Source control
Removing the source of infection is important as well and is termed ‘‘source control.’’ It includes interventions such as fluid drainage, debridement of soft tissues, device removal, and other definitive measures to restore function. The physical removal of an ongoing locus of infection should be identified or excluded as soon as possible as it can rapidly alter the course of sepsis.Interventions should start with the least invasive method (e.g., percutaneous as opposed to surgical) when possible. When vascular catheters are left indwelling, blood cultures should be sent from them. Indwelling urinary catheters should be replaced and a urine culture should be sent from the new catheter.