To present the design, methods, and rationale of the Child/Adolescent Anxiety Multimodal Study
(CAMS), a recently completed federally-funded, multi-site, randomized placebo-controlled trial that examined the
relative efficacy of cognitive-behavior therapy (CBT), sertraline (SRT), and their combination (COMB) against pill
placebo (PBO) for the treatment of separation anxiety disorder (SAD), generalized anxiety disorder (GAD) and social
phobia (SoP) in children and adolescents.