The studies by Schroder et al. and Kulnigg et al. reported an increase in SF-36 score at the end of iron replacement therapy irrespective of the route of replacement: 7–17 points increment with IV iron and 8–17 points increment with PO iron therapy. Both routes had a comparable improvement in SF 36 scores, the pooled mean difference between PO and IV was 1.4 (CI −0.7, 3.5), which was not statistically significant