Most of the gas producing bacteria are best fit for anaerobic conditions. But, human body have sufficient amount of oxygen, in this aerobic environment, we recommend to use of aerobic bacteria or bacteria which are live in both environment (presence or absence of oxygen) to produce biogas. There are many aerobic bacteria that are able to produce biogas such as H2S, NO and CO2. We can use these bacteria for radiation protection. For example, Escherichia coli is a bacterium that can grow in the absence and presence of oxygen [41]. Also reprogramming of anaerobic bacteria to grow, live and do their action in aerobic condition. This can be done by bioengineering and genetically modification. It should be mentioned that the suggested microorganisms (e.g. bacteria) for biogas production, are in adaptation with immune system and their residence in the body don’t threat the human health. But, microorganism’s lifetime varies by type and is dependent to many factors such as reproductive capacity, environment, nutrients and conditions they needs. Also, we can do genetically modification of microorganisms to do their acts in a well-established behavior such as the well enough biogas production, suitable residence time and best generation (cell cycle) time. Another way is to use antibiotics. The interesting part of this therapy is genetically manipulation of those microorganisms. Biotechno-Microbiological (BIOMIC) studies associated to genetic knowledge can help researchers to find best microorganisms with highest gas efficiency and lowest side effects and also their targeting to place of treatment.