Thus, how these findings inform our understanding of synchronized central and peripheral release patterns under basal conditions across the lifespan largely remains unclear. Further, previous studies investigating the relationship between CSF and plasma AVP
concentrations in adult animals and humans have reported mixed findings , likely due to state specific factors (e.g., the stress of forced swimming)in animals,or disease and physiological imbalance (including osmolality and natremia status) inherent in
the clinical indications that require invasive lumbar CSF sampling
in humans