support for perhaps a variant of apoptotic cell death.
111
It is important to
point out that both in experimental animals and in human disease, cell death
of dopaminergic neurons does occur in the setting of some amount of cellular
inflammation and microglial response. This may indicate that cell death for
some dopaminergic neurons may be relatively abrupt and proceed along the
pathway of accidental or necrotic cell death with attendant inflammation.
Likely, a continuum between apoptotic and necrotic cell death may occur,
with the proportion depending on the magnitude and timing of the environmental
toxin or stressor.
23,24