The only curative therapy at present for liver cancer is transplantation, but unfortunately, only 10–25% of patients qualify
for such surgical resection. The majority of patients (>80%) have
limited treatment options due to the lack of effective chemotherapy
against this malignancy, severe side effects and unprecedented
high cost [7–9]. Therefore, new drugs with higher therapeutic effi-
cacy are urgently needed to combat this malignancy [10]