However, although similar results regarding the
mRNA levels for P450 aromatase and FSH-R were observed between the cultured treatments after 18 days of culture, we observed that estradiol levels were lower in the presence of EGF 50.
These results suggest that EGF stimulated granulosa cell proliferation, but not their differentiation. Furthermore, the presence of EGF
likely modulates or inhibits the FSH-induced expression of P450