Fluorosis
is the result of subsurface hypomineralization
and porosity between
the developing enamel rods.11 This
risk exists in children younger than
8 years, and the most susceptible
period for permanent maxillary incisor
fluorosis is between 15 and
30 months of age.12–14 The risk of
fluorosis is influenced by both the
dose and frequency of exposure to
fluoride during tooth development.15
Recent evidence also suggests that
individual susceptibility or resistance
to fluorosis includes a genetic
component.