Abstract: Contact allergy (CA) is alteration of immune response with readiness to develop an inflammatory reaction
against a specific substance of low molecular weight (hapten). The prevalence of CA is estimated at 26-40% among
adults, and 21-36% children. A proportion of people with CA will remain asymptomatic, among the rest, the most frequent
clinical manifestation is allergic contact dermatitis (ACD) with lifetime prevalence estimated at 10%. Less frequent
manifestations include allergic contact stomatitis, conjunctivitis, vaginitis, systemic reactions, implant intolerance, and
rarely urticaria, asthma, and allergic rhinitis. Patch test (epicutaneous test) is the gold standard in the diagnosis of CA and
ACD: Performing the test significantly increases probability of accurate diagnosis, reduces costs of treatment, and leads to
improved patients’ quality of life. Patch test results may be influenced by patient’s medication and health status, and interpretation
requires due knowledge and experience. Other diagnostic methods are more laborious and not validated; no in
vitro tests are available for routine application at present.
Abstract: Contact allergy (CA) is alteration of immune response with readiness to develop an inflammatory reactionagainst a specific substance of low molecular weight (hapten). The prevalence of CA is estimated at 26-40% amongadults, and 21-36% children. A proportion of people with CA will remain asymptomatic, among the rest, the most frequentclinical manifestation is allergic contact dermatitis (ACD) with lifetime prevalence estimated at 10%. Less frequentmanifestations include allergic contact stomatitis, conjunctivitis, vaginitis, systemic reactions, implant intolerance, andrarely urticaria, asthma, and allergic rhinitis. Patch test (epicutaneous test) is the gold standard in the diagnosis of CA andACD: Performing the test significantly increases probability of accurate diagnosis, reduces costs of treatment, and leads toimproved patients’ quality of life. Patch test results may be influenced by patient’s medication and health status, and interpretationrequires due knowledge and experience. Other diagnostic methods are more laborious and not validated; no invitro tests are available for routine application at present.
การแปล กรุณารอสักครู่..