The rationale for the critical review was the apparent lack of consensus over the optimal dosing regimen for relapse prevention. Since the compiled data were published as supplementary files, a scatter plot of total dose (primaquine base mg/day|treatment length in days) versus % cure has been generated for studies in which primaquine was given with chloroquine. A simple Emax curve (SigmaPlot, Systat Software,ver. 11, San Jose, CA, USA) was fit to the data for illustration purposes (Fig. 2).