Patients were categorized
as having cellulitis (defined as inflammation
of the skin and associated skin structures
without signs of a drainable fluid collection), abscess
(defined as a circumscribed, drainable collection
of pus), or both (if lesions of both cellulitis
and abscess were present). Exclusion criteria
were superficial skin infections (e.g., impetigo),
skin infection at a body site that requires specialized
management (e.g., perirectal, genital, or
hand infection), a human or animal bite at the
infection site, high fever (oral temperature, >38.5°C
[>38.0°C in children 6 to 11 months of age]),
receipt of immunosuppressive medications or the
presence of an immunocompromising condition
such as diabetes or chronic renal failure, morbid
obesity (body-mass index [the weight in kilograms
divided by the square of the height in meters],
>40), surgical-site or prosthetic-device infection,
and receipt of antibacterial therapy with antistaphylococcal
activity in the previous 14 days. Patients
were ineligible if they lived in a long-term care
facility, had cancer or an inflammatory disorder
that required treatment in the previous 12 months,
or had major surgery in the previous 12 months.
All the inclusion and exclusion criteria are listed
in Table S1 in the Supplementary Appendix, available
with the full text of this article at NEJM.org.
The full protocol and statistical-analysis plan are
also available at NEJM.org.
Patients were categorizedas having cellulitis (defined as inflammationof the skin and associated skin structureswithout signs of a drainable fluid collection), abscess(defined as a circumscribed, drainable collectionof pus), or both (if lesions of both cellulitisand abscess were present). Exclusion criteriawere superficial skin infections (e.g., impetigo),skin infection at a body site that requires specializedmanagement (e.g., perirectal, genital, orhand infection), a human or animal bite at theinfection site, high fever (oral temperature, >38.5°C[>38.0°C in children 6 to 11 months of age]),receipt of immunosuppressive medications or thepresence of an immunocompromising conditionsuch as diabetes or chronic renal failure, morbidobesity (body-mass index [the weight in kilogramsdivided by the square of the height in meters],>40), surgical-site or prosthetic-device infection,and receipt of antibacterial therapy with antistaphylococcalactivity in the previous 14 days. Patientswere ineligible if they lived in a long-term carefacility, had cancer or an inflammatory disorderthat required treatment in the previous 12 months,or had major surgery in the previous 12 months.All the inclusion and exclusion criteria are listedin Table S1 in the Supplementary Appendix, availablewith the full text of this article at NEJM.org.The full protocol and statistical-analysis plan arealso available at NEJM.org.
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