Abstract— It has been widely investigated that the application of operations management techniques is not only based on technical factors, but it is mainly associated with organizational factors such as culture, previous policies and procedures, etc. A very good example of promisng operations practices is Lean Six Sigma (L6σ). The main research question for L6σ is related to its liabilities regarding its implementation and how to do it in food industry. Therefore, this paper aims to explore the impact of the new tool L6s and explain what are the critical factors related to applying L6σ. The context of the analysis is in the general view of food industry. Since it seems that it has been neglected from the literature that mainly focuses is on manufacturing and service sector (telecommunication; healthcare and airline industry). The methodology was based on the structure interviews, of the 16 companies in Europe in food sector. The 16 topmanagers will be exanimated on adequate way. The findings and results will help to give appropriate justifications, such as why food industries must apply L6σ. And also give occasion to compare with the literature review and theory. On the end it will show that there are ten (10) particular factors that influence the implementation of L6σ in food industry.