With burn injuries involving a large total body surface area (TBSA), the body can enter a state of breakdown, resulting in a condition
similar to that seen with severe lack of proper nutrition. In addition, destruction of the effective skin barrier leads to loss of normal
body temperature regulation and increased risk of infection and fluid loss. Nutritional support is common in the management of severe
burn injury, and the approach of altering immune system activity with specific nutrients is termed immunonutrition. Three potential
targets have been identified for immunonutrition: mucosal barrier function, cellular defence and local or systemic inflammation. The
nutrients most often used for immunonutrition are glutamine, arginine, branched-chain amino acids (BCAAs), omega-3 (n-3) fatty
acids and nucleotides.
With burn injuries involving a large total body surface area (TBSA), the body can enter a state of breakdown, resulting in a condition
similar to that seen with severe lack of proper nutrition. In addition, destruction of the effective skin barrier leads to loss of normal
body temperature regulation and increased risk of infection and fluid loss. Nutritional support is common in the management of severe
burn injury, and the approach of altering immune system activity with specific nutrients is termed immunonutrition. Three potential
targets have been identified for immunonutrition: mucosal barrier function, cellular defence and local or systemic inflammation. The
nutrients most often used for immunonutrition are glutamine, arginine, branched-chain amino acids (BCAAs), omega-3 (n-3) fatty
acids and nucleotides.
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