However, sensing of LPS of gut commensal bacteria can simultaneously bedisadvantageous for the genetically predisposed host, since this might lead to damage of the intestinalhomeostasis and therefore to chronic intestinal inflammation. However, less immunogenic LPS couldalso serve as therapeutics to antagonize an overreacting innate immune system. Therefore, commensalgut bacteria-derived LPS could prevent from uncontrolled intestinal immune response in the intestinewhich makes LPS an attractive therapeutical approach to treat e.g. IBD.