Effect of GAE in human epidermal equivalents
To more closely approximate human usage, a recon-
structed human skin model was used to investigate the
depigmenting activity of GAE. Kojic acid was the positive
standard, consistent with its common use for skin depig-
mentation therapy. As shown in Fig. 5, the level of
melanin decreased significantly following GAE treatment.
The depigmenting activity of 200 μg/mL GAE was com-
parable to that of 2 % kojic acid.