The impressive
number of anti-cancer drugs that are derived from natural
sources are discussed in terms of their mechanisms of action,
and as can be seen from these discussions, natural products
from all sources still have the potential to lead chemists of
all types into areas of drug discovery and development that
would never have been considered if the “privileged structures
from Nature” had not been isolated, purified, and used
as probes of cellular and molecular mechanisms. In spite of
the discussions in the early-to-late 1990s concerning the vast
potential of combinatorial chemistry as a discovery tool, it
is now quite evident that this technique, except in the very
special cases of peptides and nucleosides (which are actually
“privileged structures” in their own right), is not the panacea
that it was thought to be
The impressive
number of anti-cancer drugs that are derived from natural
sources are discussed in terms of their mechanisms of action,
and as can be seen from these discussions, natural products
from all sources still have the potential to lead chemists of
all types into areas of drug discovery and development that
would never have been considered if the “privileged structures
from Nature” had not been isolated, purified, and used
as probes of cellular and molecular mechanisms. In spite of
the discussions in the early-to-late 1990s concerning the vast
potential of combinatorial chemistry as a discovery tool, it
is now quite evident that this technique, except in the very
special cases of peptides and nucleosides (which are actually
“privileged structures” in their own right), is not the panacea
that it was thought to be
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