In the present study, major
metabolites secreted from P. falciparum are those involved in glucose
metabolism which is the source of energy. Blood stage malaria
parasite relies extensively on glucose metabolism with less consumption
of oxygen. From the previous report (MacRae et al.,
2013), the TCA cycle of the malaria parasite is bifurcated, part of
it being oxidative and the other part being reductive. The parasite
utilizes the amino acids glutamic acid and/or glutamine to maintain
its life-cycle. The two branches converge on malate, which
together with citrate, is exported from the mitochondria to cytoplasm
and finally secreted to complete media from glucose metabolism
were detected in culture medium of the parasites exposed to
G. mangostana Linn