Body weights were measured between 3 and 1 days prior to treatment to calculate doses administered on study Day 0 and on study Day 13 to calculate doses administered on study Day 14. Timing of the interval between inoculation with A. tubaeforme and treatment with the novel combination in studies 1 and 2 was designed so that the parasites were expected to be fourth stage larvae on studyDay 0 or adults on study Day 14. In the remaining studies treatment days were timed to treat adult stages ofthe parasite. All cats were observed hourly for 4 h aftertreatment