Figure1.Withinstriatumserialprocess

Figure1.Withinstriatumserialprocessingunderliestheestablishmentofcocaine-seekinghabits.(a)Schematicoftheintrastriataldopamine-dependentspirallingcircuitryfunctionallyconnectingtheventralwiththedorsalstriatumintherat(modifiedfromBelin&Everitt2008).Thespirallinglooporganizationisdepictedasthealternationofpinkandblackarrowsfromtheventraltothemoredorsalpartsofthecircuit,i.e.fromtheAcbS(yellow)totheAcbC(lightblue)viatheventraltegmentalarea(pink)andfromtheAcbC,viathesubstantianigratothedorsalstriatum(darkblue).(b)CocaineseekingisdosedependentlyimpairedbybilateralinfusionsoftheDAreceptorantagonista-flupenthixol(depictedasgreendots)intotheDLstriatum.a-FlupenthixolinfusionsintotheDLstriatumdosedependentlydecreasedrespondingontheactiveleverunderasecond-orderscheduleofcocainereinforcement,buthadnoeffectonrespondingontheinactivelever(Belin&Everitt2008).(c)DisconnectingtheAcbCfromthedopaminergicinnervationofthedorsalstriatumimpairshabitualcocaineseeking.InunilateralAcbC-lesionedrats,theAcbCrelayoftheloopislostontheonesideofthebrain.However,onthenon-lesionedside,thespirallingcircuitryisintactandfunctional.Whena-flupenthixol(greendots)isinfusedintheDLstriatumcontralateraltothelesionitblockstheDAergicinnervationfromthemidbrain,impairingtheoutputstructureofthespirallingcircuitryonthenon-lesionedsideofthebrain.Therefore,thisasymmetricmanipulationdisconnectsthecoreofthenucleusaccumbensfromtheDLstriatumbilaterallyandgreatlydiminishescocaineseeking(figureadaptedwithpermissionfromBelin&Everitt(2008)).

ผลลัพธ์ (ไทย) 1:

Figure1.Withinstriatumserialprocessingunderliestheestablishmentofcocaine-seekinghabits (a) Schematicoftheintrastriataldopamine-dependentspirallingcircuitryfunctionallyconnectingtheventralwiththedorsalstriatumintherat(modifiedfromBelin&Everitt2008) Thespirallinglooporganizationisdepictedasthealternationofpinkandblackarrowsfromtheventraltothemoredorsalpartsofthecircuit,i.e.fromtheAcbS(yellow)totheAcbC(lightblue)viatheventraltegmentalarea(pink)andfromtheAcbC,viathesubstantianigratothedorsalstriatum(darkblue). (b) CocaineseekingisdosedependentlyimpairedbybilateralinfusionsoftheDAreceptorantagonista-flupenthixol (depictedasgreendots) intotheDLstriatum.a-FlupenthixolinfusionsintotheDLstriatumdosedependentlydecreasedrespondingontheactiveleverunderasecond-orderscheduleofcocainereinforcement, buthadnoeffectonrespondingontheinactivelever (Belin และ Everitt2008) (c) DisconnectingtheAcbCfromthedopaminergicinnervationofthedorsalstriatumimpairshabitualcocaineseeking.InunilateralAcbC-lesionedrats,theAcbCrelayoftheloopislostontheonesideofthebrain.However,onthenon-lesionedside, thespirallingcircuitryisintactandfunctional Whena-flupenthixol (greendots) isinfusedintheDLstriatumcontralateraltothelesionitblockstheDAergicinnervationfromthemidbrain, impairingtheoutputstructureofthespirallingcircuitryonthenon-lesionedsideofthebrain ดังนั้น thisasymmetricmanipulationdisconnectsthecoreofthenucleusaccumbensfromtheDLstriatumbilaterallyandgreatlydiminishescocaineseeking (figureadaptedwithpermissionfromBelin & Everitt(2008))

ผลลัพธ์ (ไทย) 3:

figure1 . withinstriatumserialprocessingunderliestheestablishmentofcocaine seekinghabits ( ) schematicoftheintrastriataldopamine dependentspirallingcircuitryfunctionallyconnectingtheventralwiththedorsalstriatumintherat ( modifiedfrombelin & everitt2008 ) thespirallinglooporganizationisdepictedasthealternationofpinkandblackarrowsfromtheventraltothemoredorsalpartsofthecircuit )fromtheacbs ( สีเหลือง ) totheacbc ( color ) viatheventraltegmentalarea ( สีชมพู ) andfromtheacbc viathesubstantianigratothedorsalstriatum ( color ) , ( B ) cocaineseekingisdosedependentlyimpairedbybilateralinfusionsofthedareceptorantagonista flupenthixol ( depictedasgreendots ) intothedlstriatum .a-flupenthixolinfusionsintothedlstriatumdosedependentlydecreasedrespondingontheactiveleverunderasecond-orderscheduleofcocainereinforcement buthadnoeffectonrespondingontheinactivelever ( เบลิน , & everitt2008 ) ( C ) disconnectingtheacbcfromthedopaminergicinnervationofthedorsalstriatumimpairshabitualcocaineseeking . inunilateralacbc lesionedrats theacbcrelayoftheloopislostontheonesideofthebrain.however , ,onthenon lesionedside thespirallingcircuitryisintactandfunctional , . whena flupenthixol ( greendots isinfusedinthedlstriatumcontralateraltothelesionitblocksthedaergicinnervationfromthemidbrain impairingtheoutputstructureofthespirallingcircuitryonthenon-lesionedsideofthebrain.therefore ) , ,thisasymmetricmanipulationdisconnectsthecoreofthenucleusaccumbensfromthedlstriatumbilaterallyandgreatlydiminishescocaineseeking ( figureadaptedwithpermissionfrombelin & everitt ( 2008 )