reported [1–10]. However, our knowledge about the interrelationships
between these markers is limited. A method that groups
these markers into biologically meaningful clusters could help to elucidate
the underlyingmechanisms of collinearity. This approachmay also
assist in identifying a “biomarker superfamily” representing a novel
approach to risk stratify these patients. The hypothesis, that amultimarker
approach, measuring circulating levels of several vascular-related
markers could reveal a “signature of disease” that can serve a highly
accurate method to assess for the risk of future CV events, is currently
receivingmuch attention