Objective: This study evaluates the effects of an 8-week comprehensive pulmonary rehabilitation program (PRP) on health related quality of life (HRQoI) and exercise tolerance of COPD patients at Physiotherapy Department, University Kebangsaan Malaysia Medical Centre (UKMMC). Materials and Methods: It is a quasi experimental study involving a control group (CG) with no intervention done and an intervention group (IG) with pulmonary rehabilitation program (PRP). There were 66 subjects in IG with a mean age of 61 + 10.88 years and 57 patients in the CG with mean age 60.8 + 11.771. Results: In the IG, there were improvement in the mean score for subscales of SGRQ and the 6 Minute Walk Distance (6 MWD) was 306 ± 118 m with improvement of 68 ± 17 m. A mixed between-within ANOVA demonstrated interaction effect was significant for symptom (p = 0.001), impact (p = 0.001), activity (p = 0.001) and total score (p = 0.002). Similarly, between sub- ject effect demonstrated significant for symptom (p < 0.01), activity, (p