Despite his many popular successes, Tchaikovsky's life was punctuated by personal crises and depression. Contributory factors included his leaving his mother for boarding school, his mother's early death, as well as that of his close friend and colleague Nikolai Rubinstein, and the collapse of the one enduring relationship of his adult life, his 13-year association with the wealthy widow Nadezhda von Meck. His homosexuality, which he kept private, has traditionally also been considered a major factor, though some musicologists now downplay its importance. His sudden death at the age of 53 is generally ascribed to cholera; there is an ongoing debate as to whether it was accidental or self-inflicted.