A prospective randomized controlled study, which included
fifty COPD patients with Type II respiratory failure requiring
initial invasive MV found statistically significant difference
between groups weaned by noninvasive positive pressure
ventilation (NIPPV) and those weaned by conventional
PSV.[30] Randomization of patient groups was done after
failing a T‑piece trial. Statistically significant difference
was found between the two groups in terms of duration
of MV, weaning duration, length of ICU stay, occurrence
of nosocomial pneumonia, and outcome, each favoring
NIPPV. Authors concluded that NIPPV is a promising
weaning modality for mechanically ventilated patients and
be tried in resource‑limited settings in developing countries.