In experimental epilepsy models
BBB leakage is detected using BBB tracers, commonly by post-mortem
analysis of tracer accumulation in brain tissue. Longitudinal studies are
warranted to more specifically relate BBB dysfunction to disease progression,
which could be achieved using in vivo contrast-enhanced
magnetic resonance imaging (MRI). In patients' gadolinium (Gd)-
based MR contrast agents such as Gd-diethylenetriaminepentacetate
(Gd-DTPA) are routinely used to detect BBB opening