List of abbreviations
CD44= cell surface glycoprotein; CDC37= intracellular HA-binding protein; Da= dalton; DNA= deoxynucleotid
acid; ECM= extracellular matrix; EM= electron microscopy; GHAP= glial hyaluronate-binding protein; GIT
= gastrointestinal tract; HA= hyaluronic acid; HARE= hyaluronic acid receptor for endocytosis; HAS1, HAS2,
andHAS3= types of hyaluronan synthases 1, 2 and 3; IHABP= intracellular HA-binding protein; IMP= integral
membrane protein; IL-1= interleukine 1; LM= light microscopy; LYVE-1= lymphatic vessel endocytic receptor;
MRHD= maximum recommended human dose; NS= normal saline; OA= osteoarthrosis; P-32= protein-32;
RHAMM= receptor for hyaluronic acid mediated mobility; RHAMM/IHABP= receptor for hyaluronic acid
mediated mobility/intracellular HA-binding protein; TDLo= toxic dose low; TIMP-1= tissue inhibitor of matrix
metalloproteiness 1;TNF-α= tumor necrosis factor alpha; TSG-6= tumor necrosis factor-α-stimulated gene-6;
t
1/2
= half-life; UDP= uridine diphosphate
Contents
1. Introduction
2. History
3. Physicochemical and structural properties
3.1. Chemical structure
3.2. Solution structure
3.3. Polymer structure
3.4. Synthesis
3.5. Degradation
4. Mechanism of action
4.1. Interactions with hyaladherins
5. Pharmacokinetics
5.1. Absorption rate and concentration in plasma
5.2. Distribution
5.3. Excretion (elimination)