Birth-cohort screening with DAA plus standard treatment
increased screening, cases identified, and persons treated by the same amount as did birth-cohort screening with standard treatment, but (compared with risk-based screening) increased the number of patients achieving an SVR by 311 000 and reduced the number of deaths from HCV to 470 000 (a reduction of 121 000 deaths compared with risk-based screening). Compared with riskbased screening, birth-cohort screening increased QALYs by 532 000, medical costs by $19.0 billion, and productivity losses due to therapy by $6.7 billion. Productivity losses were not used to calculate ICER values.