During the events of Final Crisis, Batman is seemingly killed. He is replaced by Nightwing, Dick Grayson. When the new Batman takes back control of Gotham City, Catwoman remains despondent at the loss of Bruce Wayne. While contemplating her loss, and her unexplained physical weakness despite being fully recovered from her physical heart trauma, she rescues two bystanders from a new supervillain-wannabe who calls himself Boneblaster. However, her physical weakness becomes obvious when she fails to fight Boneblaster effectively. Before Boneblaster can cause her permanent harm, she is rescued by the sudden appearance of Poison Ivy. Concerned at how weak Catwoman had become, Ivy takes Selina to where she'd been staying, the home of the Riddler. Selina discovered that Ivy had apparently seduced and drugged the Riddler with her plant pheromones, keeping him in a vegetative state. She also discovered that Ivy had similarly taken Harley Quinn into her new sanctuary.