The six-year plan requires 6.98 billion baht and aims to ensure the water quality of Khlong Saen Saep meets the standards set by the Ministry of Natural Resources and Environment.
The NCPO wants to make sure the canal is not only clean, but also safe for travel.
It hopes to make it one of Bangkok's beautiful tourist attractions by the end of 2017.
The clean-up plan targets the canal in the Bangkok suburban districts of Min Buri and Nong Chok.