The starch, sugar, amylase, and amylopectin contents were 3.01–3.89 g/100 g, 35.34–60.91 g/100 g, 0.84–1.46 g/100 g, and 1.68–2.86 g/100 g, respectively, while the glycemic indices were 28.01–68.34, with African star apple (28.01) having the lowest and watermelon (68.34) the highest. Furthermore, the fruits exhibited high antioxidant properties as exemplified by their DPPH, ABTS+, OH, and NO radical scavenging abilities. Likewise, the fruits also demonstrated α-amylase and α-glucosidase inhibitory property with Soursop (IC50 = 18.52 μg/mL), guava (IC50 = 19.77 μg/mL), and African star apple (IC50 = 20.86 μg/mL) showing the highest inhibitory potential among the 13 fruits. Similarly, the same trend was followed for α-glucosidase inhibitory activity.