She was the fourth of five children of John Spencer, Viscount Althorp and his first wife, Frances The Spencer family has been closely allied with the British Royal Family for several generations.Diana had three siblings: Sarah, Jane, and Charles. Her infant brother, John,. The desire for an heir added strain to the Spencers' marriage, and Lady Althorp was reportedly sent to Harley Street clinics in London to determine the cause of the "problem". The experience was described as "humiliating" by Diana's younger brother, Charles.Lady Diana Frances Spencer married Prince Charles in 1981 and became Princess of Wales. She had two sons and later divorced in 1996.