For peptides, the mechanism of action of antimicrobial peptides seems to involve multiple targets. The plasma
membrane is the most cited target by peptides whereas recent studies have suggested intracellular targets to be more
likely for some peptides [113]. Most antimicrobial peptides have nonspecific mechanisms and they may display some
selectivity between different microorganisms. Antimicrobial peptides can assume amphipathic structures, which are
able to interact directly with the microbial cell membrane. This action rapidly disrupt the membrane in several locations
and result in the leaching out of vital cell components [75]. Studies on the mechanism of action of pleurocidin revealed that this peptide exhibits a strong membrane translocation and pore-formation ability reacting with both neutral and
acidic anionic phospholipid membranes [114].