liver, brain, and kidney tissues (Pikarsky et al. 2004),
and was previously known as carp interstitial nephritis
and gill necrosis virus. Because KHVD has be -
come so detrimental to world foodfish production,
this review will cover the discovery of KHVD, the
spread of CyHV-3, progress in our understanding of
the disease and host−pathogen relationship, tools
developed to detect the virus, and methods developed
to control the disease.