Thiazide diuretics include all diuretics believed to have a primary action to inhibit NaCl reabsorption in the distal convoluted tubule (Table 1) and have been used in the management of hypertension for over 50 years1, 2). These agents decrease blood pressure (BP) when administered as monotherapy, enhance the efficacy of other antihypertensive agents, and reduce hypertension-related morbidity and mortality. However, the use of thiazide diuretics is often limited by concerns about some metabolic change, e.g., hyponatremia, hypokalemia and insulin resistance3).