From a Micromonospora sp. in Lake Michigan sediment, we
isolated novel antibiotic molecules of the diazaquinomycin
class. An analogue, compound 3, displayed an in vitro activity
profile similar or superior to those of clinically used TB agents
and maintained potent inhibitory activity against a panel of
drug-resistant TB strains. This compound displayed a selectivity
profile targeted toward M. tuberculosis, even within the genus
Mycobacterium.