Histologically the sections of distal femur in the region proxi-
mal to the epiphyseal growth plate were examined for the changes. The alterations of bone histology
and morphology were observed including changers in cortical bone thickness, trabcular bone thick-
ness, trabcular number, osteoblasts and osteoclasts number. As shown in Table 1, in the absence of
ECH administrations, significant reductions on cortical bone thickness, osteoblasts number, trabcu-
lar thickness and number were observed in the OVX rats (p < 0.05), as well as significant
enhancement of osteoclasts number (p < 0.05) in comparison to SHAM rats. XLGB, E2 and all ECH
dosages were able to recover the changes on bone histology and morphology in the OVX rats. In
general, analyzing the indices above, there were no significant changes between the different treatment groups.