Renal function
iGFR decreased in the HPD by 9.3 4.8 and increased by 2.4 3.9 ml/min/1.73 m2 in the SPD (p Z 0.34 for time and p Z 0.38 between treatments). eGFR decreased in the
HPD from 98 to 97 ml/min/1.73 m2 while it decreased in the SPD from 91 to 90 ml/min/1.73 m2 (p Z 0.6 for time and p Z 0.9 for treatment). Albumin excretion rate
decreased in the HPD by 8.9 8.6 and increased by 1.6 13.7 mg/min in the SPD (p Z 0.82 for time and p Z 0.13 between treatments). A decrease in hyperfiltration in the group with eGFR > 120 ml/min (n Z 12) of 15 ml/min (p Z 0.001) was seen. Participants with an eGFR < 120 ml/min (n Z 33) improved their eGFR by 4 ml/min (p Z 0.03). This improvement was directly related to weight loss (r Z 0.43, p Z 0.01) in this group but not in the participants with hyperfiltration. Dietary treatment group and protein intake were not related to the change in eGFR. Baseline eGFR remained a predictor of the change even after adjusting for weight loss (p Z 0.001). The full report on renal function has been
published elsewhere [8].