Helicobacter pylori is a human gastric pathogen. Antibiotic resistance of
H. pylori has become a problem increasing the failure of H. pylori eradication. Therefore alternative
approaches are required. The aim of this study was to evaluate the anti-H. pylori activity
of Lactobacillus pentosus strain LPS16 and the mechanism of its killing effect.
Methods: The anti-H. pylori activity of LPS16 was determined by the disc diffusion test and
time killing assay. High-performance liquid chromatography analysis was used to analyze the
secreted compounds of LPS16. Sixty H. pylori strains isolated from different gastric diseases,
having different antibiotic susceptibility were collected to analyze the spectrum of anti-H. pylori
activity of LPS16. Adhesion ability of LPS16 to gastric epithelial cell lines was assayed by
flow cytometry.
Results: The anti-H. pylori activity of LPS16 depended on the secreted component, and lactic
acid mediated bactericidal activity against H. pylori. The bactericidal activity did not vary