In contrast, potential benefits decrease after radical prostatectomy among high-risk PC patients who have locally advanced or
advanced prostate cancer . It has been shown that the effects (PSA level decrement) are good after RP
based upon long-term cancer follow-up and high cancer-specific survival rates. Progression-free
survival has been shown to be improved significantly among high-risk PC patients who have been
treated with adjuvant radiation therapy immediately after RP. It has not yet been concluded if pre- or
postoperative neoadjuvant endocrine therapy would significantly improve progression free survival
after RP