The results of this study found schizophrenia patients with a history of substance used found that Thai men aged 35 to 44 living in Bangkok, during the period 7 to 12 months, the value of confidence as 100%, 40%, 60% and 40% respectively, and found that the substance two types of amphetamine and nicotine likely to have Schizophrenia with 40% and 60% respectively, the study also found interesting rules of behavior that substance use is correlated with the incidence of schizophrenia than 80%.