Puffer fish T. rubripes specimens used in this
study initially did not contain any detectable
amount of TTX (o0.01 ngTTX/mL blood and
o0.1 mg TTX/g liver). Time courses of blood concentration
of TTX after a bolus injection into
hepatic portal vein at the dosage ranging from 0.25
to 0.75 mgTTX/kg body weight are shown in Fig. 1.
The pharmacokinetic parameters are summarized
in Table 1. At the dosage of 0.25 mgTTX/kg
body weight, blood concentration of TTX was
3.0070.58 ng/mL at 3 min after the administration